GHRH/GH-Axis
CJC-1295 (with DAC) Research Peptide
CJC-1295 with DAC is a long-acting GHRH analog featuring a Drug Affinity Complex (DAC) linker that covalently binds to circulating albumin. This conjugation extends its half-life from minutes to roughly 6–8 days, producing sustained, tonic elevation of GH and IGF-1 in research models, distinct from the short, pulsatile profile of Mod GRF 1-29 (No DAC).
$59.99 — 5mg vial
| Purity | ≥99% |
| Quantity | 5mg |
| Molecular Weight | 3647.20 g/mol |
| Sequence | Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(MPA)-NH₂ |
| Category | GHRH/GH-Axis |
| Latest batch tested | 06/19/26 |
CJC-1295 (with DAC) in Research
CJC-1295 with DAC is a long-acting analog of growth-hormone-releasing hormone in which a Drug Affinity Complex (maleimidopropionic acid linker) covalently binds circulating albumin. That single modification extends the compound's half-life from minutes to days in animal pharmacology studies — the property that made it a landmark molecule in sustained GHRH-receptor research.
Supplied lyophilized at 5mg and ≥99% purity with batch-specific third-party verification. For pulsatile-release research designs, the unconjugated CJC-1295 No DAC (Mod GRF 1-29) is the matching short-acting comparator.
Research Overview
- Multi-day half-life via covalent albumin binding through the DAC linker
- Sustained elevation of baseline GH and IGF-1 in animal pharmacology studies
- Once-weekly dosing schedules investigated in preclinical work
- Reduces the pulsatile pattern of endogenous GH release
- Studied independently from Mod GRF 1-29 due to its distinct PK profile
Quality & Testing
Every CJC-1295 (with DAC) batch is verified by independent third-party HPLC and mass-spectrometry testing, with a batch-specific certificate of analysis available on the COA page.
Laboratory Handling & Storage
Lyophilized peptides are supplied as a freeze-dried powder and are most stable stored cold (2–8°C), protected from light and moisture, in the original sealed vial. Under these conditions the research literature generally reports multi-year integrity for dry peptide material.
Once reconstituted in a laboratory setting, solutions are typically stored refrigerated and used within the window appropriate to the diluent and compound; repeated freeze–thaw cycles are avoided because they can promote aggregation. See our research overview on reconstitution and lyophilization for the underlying formulation science.
Frequently Asked Questions
What does 'with DAC' mean?
DAC (Drug Affinity Complex) is a reactive linker that covalently attaches the peptide to serum albumin. In animal studies this extends circulating half-life from minutes to multiple days compared with the unconjugated analog.
When do researchers choose DAC vs No DAC?
The DAC version is used where sustained GHRH-receptor activation is the study variable; the No DAC version is used where short, pulsatile receptor activation mimicking endogenous release patterns is required.
Is CJC-1295 for human use?
No. CJC-1295 is a research compound sold for in-vitro and preclinical laboratory use only, and it is prohibited in sport by WADA.