Melanocortin Peptides
Melanotan II Research Peptide
Melanotan II is a synthetic analog of alpha-melanocyte stimulating hormone (α-MSH). It is a cyclic lactam analog that has been studied for melanocortin receptor interactions.
$39.99 — 10mg vial
| Purity | ≥99% |
| Quantity | 10mg |
| Molecular Weight | 1024.18 g/mol |
| Sequence | Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂ |
| Category | Melanocortin Peptides |
| Latest batch tested | 06/19/26 |
Melanotan II in Research
Melanotan II is a cyclic lactam analog of alpha-melanocyte-stimulating hormone (α-MSH), studied for broad agonism across melanocortin receptors (MC1R–MC5R). Its constrained ring structure gives it markedly higher receptor potency and metabolic stability than the linear parent hormone, which is why it appears widely in melanocortin-signaling research.
Supplied lyophilized at 10mg and ≥99% HPLC purity with batch-specific third-party COA documentation. For receptor-selectivity comparisons, the linear analog Melanotan I — with its narrower MC1R preference — is the natural counterpart compound.
Research Overview
- Studied for melanocortin receptor agonism (MC1R-MC5R)
- Investigated for melanogenesis pathway activation
- Research into appetite regulation mechanisms
- Explored for lipid metabolism modulation
- Preclinical studies on photoprotective potential
Quality & Testing
Every Melanotan II batch is verified by independent third-party HPLC and mass-spectrometry testing, with a batch-specific certificate of analysis available on the COA page.
Laboratory Handling & Storage
Lyophilized peptides are supplied as a freeze-dried powder and are most stable stored cold (2–8°C), protected from light and moisture, in the original sealed vial. Under these conditions the research literature generally reports multi-year integrity for dry peptide material.
Once reconstituted in a laboratory setting, solutions are typically stored refrigerated and used within the window appropriate to the diluent and compound; repeated freeze–thaw cycles are avoided because they can promote aggregation. See our research overview on reconstitution and lyophilization for the underlying formulation science.
Frequently Asked Questions
What is Melanotan II?
Melanotan II is a synthetic cyclic analog of α-MSH studied for melanocortin-receptor agonism and melanogenesis-pathway activation in laboratory models. It is an unapproved research compound.
How does Melanotan II differ from Melanotan I?
Melanotan II is cyclic and active across multiple melanocortin receptors, while Melanotan I is a linear analog with more selective MC1R affinity. The pair is often used in receptor-selectivity research designs.
How is this material verified?
Independent HPLC purity testing (≥99%) and mass-spectrometry identity confirmation on every lot, documented on the certificate of analysis available from the COA page.
Is Melanotan II for human use?
No. Melanotan II is sold strictly for in-vitro and preclinical laboratory research. It is not approved for any human use, and no human application is described or endorsed.