Mitochondrial Peptides
MOTS-c Research Peptide
MOTS-c is a mitochondrial-derived peptide encoded within the 12S rRNA gene of mitochondrial DNA. It is referenced in published research on mitochondrial-derived peptides and AMPK-pathway signaling.
$149.99 — 40mg vial
| Purity | ≥99% |
| Quantity | 40mg |
| Molecular Weight | 2174.58 g/mol |
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg |
| Category | Mitochondrial Peptides |
| Latest batch tested | 06/19/26 |
MOTS-c in Research
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA gene of mitochondrial DNA — one of the few known peptides transcribed from the mitochondrial genome. Its research literature centers on AMPK pathway activation, cellular energy homeostasis, and insulin-sensitivity signaling in preclinical models, where it is often described as an exercise-mimetic research compound.
Supplied lyophilized at 40mg per vial and ≥99% purity with batch-specific third-party HPLC and MS documentation.
Research Overview
- Investigated for AMPK pathway activation and cellular energy homeostasis regulation
- Studied for insulin sensitivity enhancement and glucose uptake modulation
- Research into exercise-mimetic effects on skeletal muscle metabolism
- Explored for age-related metabolic decline prevention in animal models
- Preclinical studies on stress response and cellular resilience mechanisms
Quality & Testing
Every MOTS-c batch is verified by independent third-party HPLC and mass-spectrometry testing, with a batch-specific certificate of analysis available on the COA page.
Laboratory Handling & Storage
Lyophilized peptides are supplied as a freeze-dried powder and are most stable stored cold (2–8°C), protected from light and moisture, in the original sealed vial. Under these conditions the research literature generally reports multi-year integrity for dry peptide material.
Once reconstituted in a laboratory setting, solutions are typically stored refrigerated and used within the window appropriate to the diluent and compound; repeated freeze–thaw cycles are avoided because they can promote aggregation. See our research overview on reconstitution and lyophilization for the underlying formulation science.
Frequently Asked Questions
What is MOTS-c?
MOTS-c is a mitochondrial-derived peptide encoded in the mitochondrial 12S rRNA gene, studied for AMPK activation and metabolic-homeostasis signaling in laboratory models.
Why is MOTS-c called an exercise-mimetic in the literature?
Animal studies report that MOTS-c administration activated metabolic pathways overlapping those induced by exercise — AMPK signaling and glucose-uptake modulation — hence the research shorthand. These are preclinical findings only.
Is MOTS-c for human use?
No. MOTS-c is supplied for in-vitro and preclinical research only and is prohibited in sport by WADA.